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pentobarbital will lessen the extent or outcome of cobimetinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration. Sturdy or moderate CYP3A inducers may perhaps minimize cobimetinib systemic publicity by >eighty% and cut down its efficacy.pentobarbital decreases amounts of ponatinib by influen